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KMID : 0606320080240010001
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Journal of Phamacetical Sciences Sookmyung Women s University
2008 Volume.24 No. 1 p.1 ~ p.10
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Novel Pharmacological Activities of Ethyl Vanillin
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Jung Hyun-Joo
Park Eun-Hee
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Abstract
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The current work aimed to assess novel pharmacological activities of ethyl vanillin (EVA) which is used as a flavoring agent for cakes, dessert, confectionary, etc. EVA exhibited an inhibitory activity in the chorioallantoic membrane angiogenesis. Anti-inflammatory activity of EVA was evaluated using the two in vivo models, such as vascular permeability and air pouch models in mice. Anti-nociceptive activity of EVA was assessed using acetic acid-induced writhing model in mice. EVA suppressed production of nitric oxide (NO) and induction of inducible nitric oxide synthase (iNOS) in the lipopolysaccharide (LPS)-activated RAW264.7 macrophage cells. However, EVA could not suppress induction of cyclooxygenase-2 (COX-2) in the LPS-activated macrophages. EVA reduced reactive oxygen species (ROS) level in the LPS-activated macrophages. EVA also suppressed enhanced matrix metalloproteinase-9 (MMP-9) gelatinolytic activity in the LPS-activated RAW264.7 macrophage cells. EVA at the used concentrations didn’t affect survival of the macrophage cells. In brief, the results imply that anti-angiogenic anti-inflammatory and anti-nociceptive activities of EVA is based on its suppressive effect on the production of NO.
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KEYWORD
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Chorioallantoic membrane, Nitric oxide, mouse, ethyl vanillin, air pouch
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